After confirming their original suspicions, the researchers were able to corroborate their hypothesis by carrying out a series of experiments on living cells. There also seem to be indications that people who engage in a significant amount of physical activity suffer from muscle problems when prescribed statins. You can unsubscribe at any time and we'll never share your details to third parties. If the benefits of lowering cholesterol aren't clear, why are so many people taking these drugs? They believe that a protein known as GILZ is responsible. Statins prevent cardiovascular disease not only by lowering blood cholesterol levels, but also by reducing vascular inflammation. "Our analysis is perhaps more comprehensive than those done in the past. Inherited high cholesterol may be common in people with heart disease . The pharmaceutical researchers led by Alexandra K. Kiemer are therefore planning a new study to be conducted in collaboration with the sports medicine physician Anne Hecksteden from the research group headed by Professor Tim Meyer at Saarland University. "The acronym GILZ stands for glucocorticoid-induced leucine zipper," explains Professor Kiemer. Apart from any fair dealing for the purpose of private study or research, no Science X Daily and the Weekly Email Newsletter are free features that allow you to receive your favorite sci-tech news updates in your email inbox, New study may have the reason why heart medication gives muscle pain, 'Turncoat' macrophages in the tumor 'micro-environment' underlie breast cancer progression, Immune responses during embryo development could increase risk of schizophrenia, Using haptic feedback to improve enhanced force control of piano keystrokes in elite players, Stanford team creates cellular atlas of the human lung, Australian study suggests true COVID-19 infection rate is 6.2 times higher than official tallies (Update). LDL is just one component of the cardiovascular disease process," he said, adding that just correcting LDL may not be enough to make a difference in the risk of heart disease, stroke and death. Lloyd-Jones said if you have a high risk of heart disease or stroke, it's important not to just stop taking statins and other cholesterol drugs. American. If you have questions or concerns about cholesterol medications, there are better-designed studies to answer these questions. The study has been published in The FASEB Journal under the title "The Glucocorticoid-Induced Leucine Zipper Mediates Statin-Induced Muscle Damage.". The information presented on this website is not intended as specific medical advice and is not a substitute for professional medical treatment or diagnosis. They assessed the data in terms of whether statins influenced the production of GILZ in the body. In a recent study, the pharmaceutical scientists Professor Alexandra K. Kiemer und Jessica Hoppstädter from Saarland University have identified a potential causal relationship. Newsmax, Moneynews, Newsmax Health, and Independent. A recent study – the longest ever into statins - carried out by scientists at Imperial College, London, and the University of Glasgow, (published in September 2017), produced interesting results. Get latest News Information, Articles on Railway Stations Updated on September 18, 2020 09:01 with exclusive Pictures, photos & videos on Railway Stations at Latestly.com Support us. Patients who take statins in order to lower their blood cholesterol levels often complain about muscle problems, typically muscle pain. August 4, 2020 | Tom Tillison | Print Article. Statins are also very effective at stabilizing the plaque that is already there, and are extremely effective at lowering the risk of heart attacks and strokes. That's why we thought there might be a connection between statins and GILZ. Five reported a reduction in heart attacks and strokes. Your feedback will go directly to Science X editors. May 29, 2020. Visit BBC News for up-to-the-minute news, breaking news, video, audio and feature stories. Categories: Cholesterol | Tags: Cholesterol, Food & Nutrition News, Prevention. The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. "This is not like an antibiotic where you can treat for a week and then stop," he said. "We have some evidence that there is a link between statins, physical activity and the GILZ protein, and our plan is to shed more light on how these factors interact with each other," says Professor Kiemer. Dr. Donald Lloyd-Jones, president-elect of the American Heart Association (AHA), thinks the latest research relied on questionable studies and remains a proponent of cholesterol-lowering drugs. The Cochrane Reviews — known for superb methodology — found that the more LDL-lowering we get, the better the outcomes for the groups that are treated," he said. Click here to sign in with and Terms of Use. The precise nature of the bodily processes that induce symptoms of muscle impairment has not yet been fully characterized. New study says statins and other cholesterol drugs may not reduce risk of heart disease after all. But, DuBroff added, "Don't be misguided into thinking that you can take a statin and then not pay attention to other risk factors. "Statins cause an increase in the cellular production of the GILZ protein. By William Harwood November 16, 2020 / 7:59 AM / CBS News In 2018, more than 6 million patients in Germany were treated with statins. They're a huge win for preventive medicine," Lloyd-Jones said. However, it is not uncommon for patients on statins to complain of muscle pain or muscle weakness. US Election 2020. They are also inexpensive. are registered trademarks of Newsmax Media, Inc. Newsmax TV, and Newsmax World are trademarks of Newsmax Media, Inc. Pa. Judge Opines State's Mail-in Ballot Procedures Likely Illegal... Pennsylvania High Court Rejects Lawsuit Challenging Election... Biden Considering Cindy McCain for UK Ambassador Role... House GOP: Censure Dem for Complaint in Trump Legal Team... Carter Page Suing FBI, DOJ for $75M Over Surveillance... Pa. Judge Opines State's Mail-in Ballot Procedures Likely Illegal, Pennsylvania High Court Rejects Lawsuit Challenging Election, Biden Considering Cindy McCain for UK Ambassador Role, House GOP: Censure Dem for Complaint in Trump Legal Team, Carter Page Suing FBI, DOJ for $75M Over Surveillance. Neither your address nor the recipient's address will be used for any other purpose. DuBroff said that the researchers found that the degree of reduction in LDL cholesterol didn't have any correlation with decreasing heart attacks, strokes or death. The AHA says that high-quality evidence from large randomized controlled trials have shown that statins are effective at bringing LDL levels and heart risks down. BBC News provides trusted World and UK news as well as local and regional perspectives. Over the years, her research group has conducted numerous experimental studies into this particular protein. Older patients and female patients appear to be at greater risk of developing these symptoms, but so too are patients that are very physically active," explains Alexandra K. Kiemer, Professor of Pharmaceutical Biology at Saarland University. "I think it's a decision between a patient and a provider," he said. Hundreds of millions of people worldwide take cholesterol-lowering drugs, like statins, but now a new review suggests that many folks don't benefit from these medications. The drugs are usually well tolerated and have a low risk of side effects. "I don't think the review's conclusions are supported by science. Total: 408; SHARE 398; TWEET 9; EMAIL 1 … We do not guarantee individual replies due to extremely high volume of correspondence. Keep discussions on topic, avoid personal attacks and threats of any kind. Alexandra K. Kiemer and her research group may now have identified the actual cause of the muscle pain affecting patients receiving statins. It's Cholesterol Education Month, a good time to protect your health by sorting out the sometimes-confusing facts. DuBroff said he thinks the guidelines for using cholesterol-lowering medicines may "need to revisit some of this negative or contradictory evidence. SpaceX launches 4 astronauts to space station, beginning new era for NASA. By using our site, you acknowledge that you have read and understand our Privacy Policy The latest breaking news, comment and features from The Independent. The researchers said the review of 35 randomized controlled trials failed to show a consistent benefit in lowering the risk of heart attack or stroke, or for preventing deaths. Sep 16, 2020. Hundreds of millions of people worldwide take cholesterol-lowering drugs, like statins, but now a new review suggests that many folks don't benefit from these medications. Of these 13 studies, only one saw a reduced risk of death. This site uses cookies to assist with navigation, analyse your use of our services, and provide content from third parties. But we're not the first to raise these concerns. Your email address is used only to let the recipient know who sent the email. Your opinions are important to us. Thank you for taking your time to send in your valued opinion to Science X editors. The research team then tried switching off the GILZ protein in living cells and observing what effect the statins then had. Does this mean DuBroff thinks patients should dump their cholesterol-lowering drugs? In addition, the formation of muscle fibres is inhibited," says Alexandra K. Kiemer. You can be assured our editors closely monitor every feedback sent and will take appropriate actions. This document is subject to copyright. While the latest research first looked at 35 randomized controlled trials of cholesterol-lowering drugs, only 13 of the studies lowered LDL (the "bad" cholesterol) levels enough to be included in the review. "Normally, when you have a theory that says something is beneficial, it should be beneficial all the time, but not all of these studies show the benefit," said study author Dr. Robert DuBroff. More information: Jessica Hoppstädter et al, The glucocorticoid‐induced leucine zipper mediates statin‐induced muscle damage, The FASEB Journal (2020… But why this occurs is still largely unresolved. He noted that most experts agree that LDL cholesterol plays a critical role in the development of plaques that stiffen blood vessels. Get weekly and/or daily updates delivered to your inbox. A significant amount of physical activity suffer from muscle problems have been found occur. 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